ARIZONA CARDINALS VS. SAN FRANCISCO 49ERS

Arizona Cardinals vs. San Francisco 49ers
The NFC West rivalry returns to Levi’s® Stadium on Sunday, September 27, 2026, when the Arizona Cardinals take on the San Francisco 49ers in a Week 3 showdown. Kickoff is scheduled for 1:05 p.m. PT in Santa Clara, California, bringing another Sunday of NFL football to the Bay Area and putting two familiar division rivals on the same field.

The Cardinals and 49ers have a long-running history that stretches back decades, with their rivalry becoming a regular NFC West matchup following the NFL’s 2002 realignment. Every meeting carries added significance because both teams are competing within the same division, where wins can become especially valuable as the season progresses. The 49ers currently lead the all-time series, while recent games have continued to produce competitive results and memorable moments.

For San Francisco fans, the September 27 game also comes with an opportunity to enjoy one of the special experiences planned for the 2026 home schedule. The 49ers are celebrating Latino Heritage Month during the Cardinals matchup, recognizing the histories, cultures, and contributions of Latino Americans. Fans attending the game can expect the usual energy of a Levi’s Stadium gameday alongside programming connected to the celebration.

The matchup also features a special fan giveaway: attendees can receive a George Kittle bobblehead, presented by Novartis, commemorating the All-Pro tight end.

Whether you follow the 49ers, travel from Arizona to support the Cardinals, or simply enjoy the intensity of divisional football, this Week 3 contest offers a chance to experience an established NFL rivalry in person. Join the Faithful at Levi’s® Stadium in Santa Clara on September 27 for an afternoon of football, tradition, and NFC West competition as the Arizona Cardinals face the San Francisco 49ers.